Mrsa and dating
is a versatile pathogen capable of causing a wide range of human diseases.However, the role of different virulence factors in the development of staphylococcal infections remains incompletely understood.The distribution of some virulence factors is related to clonal type, whereas the presence of others is unrelated to genetic background .In this regard, it is important to note that there is limited information on the expression of these genes during infection. Using multilocus sequence typing (comparing the internal sequences of 7 housekeeping genes), Enright et al.
Expression of MSCRAMMs generally occurs during logarithmic growth (replication), whereas secreted proteins, such as toxins, are produced during the stationary phase.Peptidoglycan, lipoteichoic acid, and α-toxin may all play a role [22–24] (reviewed by Lowy ).In addition to causing septic shock, some strains produce superantigens, resulting in various toxinoses, such as food poisoning and toxic shock syndrome [25, 33].In addition, is also capable of producing septic shock.
It does this by interacting with and activating the host immune system and coagulation pathways.
MSCRAMMs appear to play a key role in initiation of endovascular infections, bone and joint infections, and prosthetic-device infections. In vitro, is also able to form small-colony variants (SCVs), which may contribute to persistent and recurrent infection.