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A meta-regression model was fitted adjusting for baseline odds by fitting it as a covariate, to obtain the pooled odds ratio of 1.54 (95% CI, 1.16 to 2.01) from Bayesian analysis and 1.52 (95% CI, 1.27 to 1.82, P CONTRIBUTIONS OF AUTHORS Richard Baker, Francine Cheater and Elizabeth Shaw were responsible for the planning of the review.

Janette Camosso-Stefinovic was responsible for developing, editing and running search strategies for the review, in collaboration with three successive EPOC Trials Search Coordinators: Jessie Mc Gowan, Doug Salzwedel and Michelle Fiander.

The effect sizes of these studies varied both across and within studies.

Twelve studies provided enough data to be included in the quantitative analysis.

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However, the methods used to identify barriers and tailor interventions to address them need further development.

DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed quality and extracted data. We carried out a meta-regression to compare interventions tailored to address identified barriers to change with either no interventions or an intervention(s) not tailored to the barriers.2.